Comprehensive Gynecology, 5th Edition by Vern L. Katz MD, Gretchen Lentz MD, Rogerio A. Lobo MD,

By Vern L. Katz MD, Gretchen Lentz MD, Rogerio A. Lobo MD, David Gershenson MD

Previously edited via Drs. Droegemueller, Stenchever, Mishell & Herbst - this relied on and established reference offers entire, well timed, and simple entry to important info at the clinical and surgical matters affecting modern-day day-by-day gynecology perform. that includes the clean views of 4 new editors, besides new participants, the textual content deals useful, in-depth coverage...helpful illustrations - many new to this edition...and clinically orientated guidance...page after web page! Plus, entry the full contents on-line, absolutely searchable at www.compgyn.com - so that you can locate speedy solutions from an location.Access state of the art information at the most recent minimally invasive surgical techniques...the most recent purposes in diagnostic and interventional ultrasound...and many different crucial facets of modern-day perform. entry clean perform views from 4 new editors and new participants. successfully deal with the emotional elements of the distinctiveness with specified new chapters protecting rape * incest * and household violence, between others. Diagnose stipulations thoroughly with the visible relief of approximately 1,000 illustrations - together with greater than a hundred new full-color photos.Quickly locate the data you would like with simple positive factors together with key words, key issues, and using colour throughout.Exponentially enhance your scientific reference strength with entry to the full contents on-line - absolutely searchable - in addition to all the illustrations to be used in digital shows. stopover at www.compgyn.com for details.Presents the paintings of 4 new affiliate editors and lots of new participants who provide clean perform perspectives.Includes certain new chapters overlaying rape · incest · household violence · and different hugely emotional points of the specialty.Features greater than a hundred new full-color photographs that assist you establish lesions and interpret pathologic findings.Provides accelerated fabric on menopause, reflecting the ever-increasing getting older sufferer inhabitants.

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Nuclear DNA Mutations Mitochondrial DNA Mutations Table 2-4 The most significant characteristic of mitochondrial diseases caused by mutations in mtDNA is that they are all maternally inherited. Leber’s hereditary optic neuropathy (LHON) is a well known mitochondrial disease in which rapid, bilateral loss of central vision occurs. Males and females are affected equally, and all affected individuals are related through maternal lineage. This is because the cytoplasm of the ovum is abundant with mitochondria, but the sperm contain very few mitochondria.

Variable expressivity describes the severity of the phenotype in individuals who have the mutation. Some autosomal dominant conditions have a clear clinical demarcation between affected and unaffected individuals. However, some conditions express the clinical consequences of Figure 2-14. Pedigree illustrating autosomal recessive inheritance. Here, the parents of the affected children are first cousins as denoted by the double line connecting them. ) the mutation in varying degrees among members of the same family and between different families.

In the previous section, the diseases and their inheritance patterns were due to mutations that were passed on from generation to generation in a stable form. That is, all affected members in a family had the identical inherited mutation. In 1991, however, a number of reports began to describe a new class of genetic Table 2-3 conditions in which the gene mutation was dynamic and would change with different affected individuals within a family. The most common group of disorders is known as triplet, or trinucleotide-repeat, disorders.

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