By J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin
Absolutely up to date and revised, the second one variation of An Atlas of Gynecologic Oncology offers a whole description of the investigative and surgeries performed by means of the gynecologic oncologist. Key positive aspects of this significant textual content comprise:
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The former includes some nucleosides, lipid-associated sialic acid, polyamines and other metabolites. However, it is the macromolecular tumor markers that form the largest subgroup and have been most useful in the clinical management of cancer. They are either enzymes, hormones, receptors, growth factors, biological response modifiers or glycoconjugates. Ideally, tumor markers should be tumor-specific, should be produced in sufficient amounts to allow detection of minimal disease and should quantitatively reflect tumor burden.
1994). While M-CSF may have a role in differential diagnosis and screening (Suzuki et al. 1993, Woolas et al. 1993, van Haaften-Day et al. 2001), it is not useful in the follow-up of women with advanced ovarian cancer (Gadducci et al. 1998). Suzuki et al. (1998) have suggested that serum M-CSF may be highly sensitive and specific for malignant germ cell tumors of the ovary, especially dysgerminoma. Cytokeratins Cytokeratins are intermediate filaments that are part of the cytoskeleton of all epithelial cells.
1996, Zalel et al. 1996). It accurately predicts the presence of yolk sac elements in mixed germ cell tumors (Olt et al. 1990). Human chorionic gonadotrophin Human chorionic gonadotrophin (hCG) is synthesized in pregnancy by the syncytiotrophoblast. It is a glyco-protein hormone made up of two dissimilar noncovalently linked subunits termed a and β. Tumor production of hCG is accompanied by varying degrees of release of the free subunits into the circulation. In patients with gestational trophoblastic disease (hydatiform mole, invasive mole and choriocarcinoma) hCG is elevated in virtually all cases and serves as an ideal tumor marker.