By Michael J. Strong
Over the last ten years, there was an expanding reputation that syndromes of frontotemporal disorder (FTD) are a typical prevalence in sufferers with amyotrophic lateral sclerosis (ALS). Such syndromes might be found in as many as 60% of sufferers with ALS. Conversely, the prevalence of motor neuron disorder in sufferers with clinically natural frontotemporal dementia is more and more well-known. this means that to some degree there are overlapping syndromes during which either ALS and FTD take place in the related person.
This quantity summarizes the advances in our figuring out of those problems, in addition to the aptitude dating among the 2. Key subject matters contain advances in our skill to clinically describe the frontotemporal syndromes, preclinical detection, neuroimaging, and genetics. The exploding box of latest markers in neuropathology is tested, as is the position of latest genetic mutations in DNA/RNA delivery platforms. This booklet is the fundamental reference textual content for this subject, and should be of curiosity to neurologists and neurological trainees with a medical or study curiosity within the FTDs or ALS, neuropsychologists, neuropathologists, and researchers.
Read or Download Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias PDF
Similar laboratory medicine books
Laboratory Animals in study and educating includes important details that faculty and highschool teachers might want to identify and keep laboratories at their associations. the amount bargains functional recommendation approximately administrative issues, moral matters, and the tips and laws for the care and feeding of animals.
Molecular Pathology of Gynecologic melanoma specializes in placing winning molecular options into perform for the therapy of gynecologic melanoma. the amount starts off with an explication of the editors’ speculation that melanoma is principally a sickness of the mobile cycle, in response to the deregulation of the physiological strategy of mobilephone copy.
Additional resources for Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias
Gajdusek DC. (1977). Unconventional viruses and the origin and disappearance of kuru. ), Les Prix Nobel en 1976, pp. 167–216. Stockholm. 4. Prusiner SB. (2003). Prions. ), Nobel Lectures, Physiology or Medicine 1996–2000. , Singapore. 5. Gajdusek DC. (1963). Motor-neuron disease in natives of New Guinea. N Engl J Med, 268, 474–476. 6. Garruto RM, Yase Y. (1986). Neurodegenerative disorders of the western Pacific: the search for mechanisms of pathogenesis. Trends Neurosci, 9 (Suppl 12), 368–374.
1983). Epidemiological surveillance of amyotrophic lateral sclerosis and parkinsonism-dementia in the Commonwealth of the Northern Mariana Islands. Ann Neurol, 13, 79–86. 136. Waddington CH. (1942). The epigenotype. Endeavour, 1, 18–20. 137. Waddington CH. (1953). Genetic assimilation of an acquired character. Evolution, 7, 118–126. 138. Waddington CH. (1956). Genetic assimilation of the bithorax phenotype. Evolution, 10, 1–13. 139. ). (1996). Epigenetic Mechanisms of Gene Regulation. Cold Spring Harbor Laboratory Press, Woodbury.
J Neurol Sci, 165 (Suppl 1), S14–S20. 35. Traynor BJ, Codd MB, Corr B, et al. (2000). Clinical features of amyotrophic lateral sclerosis according to the El Escorial and Airlie House diagnostic criteria. Arch Neurol, 57, 1171–1176. 36. Mortara P, Chio A, Rosso MG, et al. (1984). Motor neuron disease in the province of Turin, Italy, 1966–1980. Survival analysis in an unselected population. J Neurol Sci, 66, 165–173. 37. Mortara P, Bardelli D, Leone M, et al. (1981). Prognosis and clinical varieties of ALS disease.